Harnessing Structural Biology to Unlock Molecular Glues, Bifunctional Degraders & Ternary Complex Dynamics
- Apply X-ray crystallography, Cryo-EM, and proteomics to elucidate neosubstrate recruitment, neomorphic interactions, and degradative mechanisms
- Showcase structure-guided and computationally driven design of molecular glues and PROTACs to expand the druggable target space
- Characterize transient and low-affinity ternary complexes to understand cooperativity, conformational plasticity, and multi-domain binding modes
- Integrate structural insights with predictive modeling to stabilize complexes and overcome translational barriers in next-generation TPD therapeutics