Advancing Drug Discovery in Complex Biology by Integrating Cryo-ET into the Structural Biology Toolbox
- Demonstrating how Cryo-ET complements Cryo-EM and computational approaches to resolve heterogeneity in large molecular complexes
- Case studies where Cryo-ET combined with modeling (e.g. AlphaFold) enables structural insights into viruses and challenging biological assemblies
- Practical considerations: sample prep, overcoming technical hurdles, and leveraging maps for better modelling of complex assemblies
- Exploring the role of Cryo-ET within an integrated workflow to accelerate mechanism-driven drug discovery