Applying Structural Biology to Targeted Protein Degradation to Understand Molecular Glue & PROTAC Interactions Beyond Conventional SBDD
2:30 pm - Wednesday 3rd February 2027
- Characterizing degrader-induced protein interactions using structural approaches to understand how molecular glues and PROTACs engage targets and form productive complexes
- Comparing structural observations with functional degradation data to distinguish biologically meaningful interactions from artefacts arising during structural analysis
- Using structural insights to guide degrader design and optimization to improve understanding of target engagement and support more rational TPD development
