Discovery of DA003 a Potent Small Molecule Antagonist of MRGPRX2

• Leveraging structural information to establish computational screening methods
• Disclosure of an inactive state structure of MRGPRX2 in complex with multiple ligands
• Identification of a clinical candidate DA003 as a potent selective antagonist of MRGPRX2

Speakers:

Alpay Seven

Head of Structural Biology

Deep Apple Therapeutics