Structural & Functional Basis of PU.1-BAF Interaction Enables Targeting of Lineage-Specific Transcription

• First high-resolution structure of a human transcription factor–BAF complex revealed, mapping the PU.1–BAF binding interface
• Biochemical studies define the molecular determinants of PU.1–BAF interaction, a key driver in lineage-specific transcription
• Identification of potential small-molecule inhibitors offers a new therapeutic strategy to disrupt aberrant TF–BAF activity in cancer

Speakers:

Yunji Davenport

Director, Head of Protein Biochemistry & Structural Biology

Foghorn Therapeutics