Exploring the unique hurdles of designing drugs for RNA, PROTACs, and beyond. Panellists will discuss structural and physicochemical challenges, computational and biophysical tool limitations, permeability and delivery barriers, and the need for novel screening and optimization strategies to unlock these emerging therapeutic modalities.

Discussion Points:

• What structural and physicochemical features make RNA, macrocycles, and PROTACs especially challenging compared to small molecules?
• How can computational chemistry, structural biology, and biophysics be adapted to better interrogate these modalities?
• What strategies are most promising for improving permeability, stability, and delivery of large or complex molecules?
• How can we build robust optimization workflows to balance potency, selectivity, and drug-like properties across different modalities?