Scaling Cryo-EM Across the Structural Biology Pipeline Through Microfluidic Sample Preparation, Multiplexed Analysis & Automated Data Processing

• Advancing microfluidic sample preparation and multiplexed cryo-EM workflows to increase sample-processing capacity and enable the analysis of multiple antibody–antigen specificities from a single sample
• Applying cryo-EM for polyclonal epitope mapping to rapidly resolve heterogeneous antibody responses, identify distinct antigenic specificities and reduce the need for extensive downstream monoclonal antibody screening
• Automating cryo-EM data collection and processing workflows to accelerate structure determination, standardize analysis and generate actionable outputs across larger numbers of samples

Speakers:

Julianna Han

Senior Staff Scientist, Ward Lab

The Scripps Research Institute