Structural Biology Enabled Discovery of Molecular Glue Degraders With Non-Canonical Binding modes
11:30 am - Thursday 4th February 2027
- C4 Therapeutics’ Molecular Glue discovery platform has identified novel degrader hits for several targets of high therapeutic interest
- Structural characterization revealed several non-canonical binding modes, expanding the potential target space beyond the prototypic G- and RT-loop motifs
- Early structure enablement accelerated molecular glue development into potent degrader molecules with optimal properties for further drug development
