Structure-Guided Engineering of FGFR/β-Klotho Agonistic Antibodies to Enhance Clustering & Functional Activation
- Illustrate how structural modeling informed the transition from a conventional bispecific format to a 2+1 configuration, boosting receptor activation from 30% to 70%
- Share optimization strategies across linker design, Fab vs. scFv formats, and IgG subclass backbones to enhance clustering efficiency and functional activity
- Highlight the iterative design process, including Fc modifications to balance effector function, and lessons learned for applying structure-based design to complex antibody engineering challenges