Utilizing SBDD to Enable New E3 Ligases for Targeted Protein Degredation
2:30 pm - Thursday 5th February 2026
- Discovery of ligands that recruit alternative E3 ligases for use in hetero-bifunctional PROTAC degraders
- Applying structure-guided modifications to develop an initial hit to a molecule with nanomolar potency
- Discuss how ligand discovery enables functional validation of new E3 ligases