Dietmar Weichert
Principal Scientist Boehringer Ingelheim
Seminars
Thursday 5th February 2026
Structure-Guided Discovery of GPR55 Inverse Agonists Reveal an Atypical & Glycosylation-Dependent Activation Mechanism
11:30 am
- High-resolution inactive-state structures of GPR55 with inverse agonists enable the design of an improved tool compound
- Functional characterization and structural basis of a glycosylation site mutation switching antagonist to agonist efficacy
- Comparison of active and inactive-state structures complemented by functional mutagenesis as well as hydrogen-deuterium exchange studies verify an atypical receptor activation mechanism
