Jeff Holden
Director & Head of Structural Biology Vilya Therapeutics
Jeff Holden is Director and Head of Protein Sciences and Structural Biology at Vilya, where he leads efforts to advance innovative protein-based therapeutics through the integration of structural biology, protein engineering, and drug discovery. Prior to joining Vilya, he served as Senior Scientist at Graphite Bio, supporting the development of genome editing technologies. Jeff spent more than five years at Genentech, where he worked at the intersection of structural biology, biochemistry, and computational biology, developing novel approaches for peptide and macrocycle design. Throughout his career, he has applied cutting-edge structural and computational methods to accelerate therapeutic innovation.
Seminars
- Scaling automated X-ray crystallography and structural biology workflows to rapidly generate structures across large numbers of targets
- Integrating automation and AI-driven workflows to accelerate the path from raw experimental data to partially refined structures and actionable structural insights
- Applying high-throughput structural approaches to emerging modalities, including macrocycles and peptides, to expand the scope of structure-based drug discovery beyond conventional small molecules
