Discovery & Optimization of NEO-811, a First-in-Class Molecular Glue Degrader of ARNT, Utilizing Structure-Based Drug Design
12:00 pm - Wednesday 3rd February 2027
- Applying Cryo-EM to resolve ternary complex structures and guide targeted protein degradation strategies
- Leveraging structural insights to accelerate the preclinical characterization and optimization of NEO-811
- Interrogating the neosubstrate–ligase interface to understand the molecular basis of degradation
